Breath tests for personalized medicine

Who likes to be pricked by a needle? According to our project target an alternative solution will be: Please breathe!

FEMBREATH encouraged pupils to detect volatile organic compounds as disease markers supported by our scientists and developed new medical breath tests. FEMBREATH supported the interest of pupils for technical studies, and connected the schools involved with university research more closely. The pupils contributed to all research tasks actively, such as scientific literature search, working in clinical environment, lab work, measurements with analytical devices, biostatistical analysis and data interpretation.

FEMBREATH validates a breath test for measurement of the activity of the enzyme Cytochrom P 450 2C19 (CYP2C19) which is important for patients undergoing cardiovascular therapy with the drug Clopidogrel. The activity of CYP2C19 differs in individual patients: depending on its activity, the effectiveness of Clopidogrel therapy can vary. Therefore our breath test delivers important information for the individual patients. Furthermore, the analysis of human breath for cancer diagnosis is investigated. Linus Pauling, a double Nobel Prize Laureate, was the breath research pioneer. He discovered that human breath contains around 200 volatile organic compounds. The most prominent breath test allows detection of infection with helicobacter pylori bacteria in the gut – similarly it could be possible to develop breath tests for early cancer diagnosis, diabetes, liver and renal diseases by breath analysis. FEMBREATH attached value on equity of both sexes in research.

FEMBREATH is an outstanding science center in the Austrian provinces of Vorarlberg and Tyrol to support pupils in natural science and technical studies. It facilitated for pupils to get in touch with our fascinating research field. Partners in the project were the University of Innsbruck, five high schools, the Slovak National Academy of Sciences, Innsbruck Medical University, the University of Applied Sciences in Dornbirn and an international scientific society.

This project has been completed.